Ultrasound-based multimodal molecular imaging and functional ultrasound contrast agents (UCAs) have garnered great interest
in biomedical imaging over the past few years. With the rapid development of molecular imaging technique, UCAs with singlefunction
and single imaging modality can no longer satisfy increasingly growing medical diversification and hominization demand. The
device of functional UCAs including multimodality and multifunction is of great value for disease diagnosis, treatment and research, and
greatly accelerate the development of ultrasound-based multimodal molecular imaging. Functional UCAs can not only be applied for
multimodality imaging to compensate for the disadvantages of each imaging modality whilst taking advantage of their individual
strengths to acquire more biological information, but also can act as a vector carrying drugs or therapeutic genes to accomplish the combination
of diagnosis and treatment, which is an existing study hotspot and has achieved initiatory success. In this paper, we reviewed the
advances of ultrasound-based multimodal imaging, multimodal and multifunctional UCAs.
Keywords: Ultrasound, contrast agent, multimodality, multifunction, diagnosis, treatment.
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