The Ubiquitin Proteasome System as a Potential Target for the Treatment of Neurodegenerative Diseases

Author(s): Zheng Ying, Hongfeng Wang, Guanghui Wang

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 18 , 2013

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Abstract:

Neurodegenerative diseases are severe disorders characterized by progressive neurodegeneration in specific brain regions. The ubiquitin-proteasome system (UPS) is closely linked to neurodegenerative disease. In most cases, UPS impairment and dysregulation of the UPS components are frequently observed. Moreover, toxin-induced neurodegeneration produces neuronal cell death accompanied by decreased UPS function. These studies suggest an involvement of the UPS in these diseases. In this review, we summarize the changes to UPS components in neurodegenerative diseases and the association between the UPS and disease pathology. Dysfunction of the UPS results in the abnormal accumulation of proteins; thus, the UPS plays a critical role in disease pathogenesis. Drugs targeting specific components of the UPS may provide promising strategies for disease treatment.

Keywords: Ubiquitin-proteasome system, deubiquitination, Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis.

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Article Details

VOLUME: 19
ISSUE: 18
Year: 2013
Page: [3305 - 3314]
Pages: 10
DOI: 10.2174/1381612811319180013
Price: $65

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