Smad ubiquitylation regulatory factor-1 (Smurf1) is a HECT-type ubiquitin ligase. The role of Smurf1 in cell development and
migration, viral autophagy and immune responses has been the subject of intensive study in recent years. Smurf1 regulates multiple biological
networks, including TGF-β and BMP signaling pathways, the non-canonical pathway and the Toll-like receptor pathway, and is
linked to certain diseases and disorders, such as bone formation and embryonic development disorders. Increasing evidence suggests that
Smurf1 could be a good candidate for further translational studies and a potential target for novel drug design. In this review, we summarize
the physiological functions of Smurf1 and its associated disorders; and discuss the current state of drug discovery in the context of
the ubiquitin-proteasomal system, and feasible pharmaceutical strategies toward Smurf1 and its regulators, as well as RNA interference
and structure-based chemical drug selection.
Keywords: Ubiquitylation, Ubiquitin ligase, HECT domain, Nedd4 family, Smurf1.
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