Dissecting Bortezomib: Development, Application, Adverse Effects and Future Direction

Author(s): Biyin Cao, Jie Li, Xinliang Mao

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 18 , 2013

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Bortezomib is the first-in-class proteasome inhibitor which has been used worldwide for the treatment of multiple myeloma and mantle cell lymphoma. Bortezomib is under evaluation as a single agent or in combination with other drugs for solid cancers and stem cell transplantation in clinical settings. However, adverse effects and drug resistance have been observed in patients, which is now emerging as a great challenge for the extended application of bortezomib. In this review, we will comprehensively discuss the development of bortezomib, the mechanism underlying its therapeutics, adverse effects and resistance. Second generation of bortezomib and its future directions will also be discussed.

Keywords: Proteasome inhibitor, bortezomib, adverse effect, resistance.

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Article Details

Year: 2013
Page: [3190 - 3200]
Pages: 11
DOI: 10.2174/13816128113199990338
Price: $65

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PDF: 47