Abstract
Lysophospholipids (LPLs) are secreted physiologically by various cell types. They exhibit a broad range of biological activities, playing highly important roles in the development, activation and regulation of the immune system and are also related to cancerous cells proliferation. Consequently LPLs or their receptors have become attractive targets for developing drugs specially in the treatment of cancers. Then the development of new synthetic methods for the preparation of LPLs is a challenging problem because the elucidation of the mechanistic details involved in the enzymological, cell-biological and membrane–biophysical roles of LPLs relies obviously on the availability of structurally diverse compounds. We will focus our attention on the chemical and enzymatic synthesis of LPLs and on the biological activity in particular of three LPLs, namely 2-lysophosphatidylcholine (2–LPC), lysophosphatidic acid (LPA) and sphingosine– 1–phosphate (S1P).
Keywords: Lysophospholipids, lysophosphatidylcholine, lysophosphatidic acid, sphingosine–1–phosphate, second messenger.
Current Organic Chemistry
Title:Lysophospholipids: Synthesis and Biological Aspects
Volume: 17 Issue: 8
Author(s): Paola D’Arrigo and Massimo Scotti
Affiliation:
Keywords: Lysophospholipids, lysophosphatidylcholine, lysophosphatidic acid, sphingosine–1–phosphate, second messenger.
Abstract: Lysophospholipids (LPLs) are secreted physiologically by various cell types. They exhibit a broad range of biological activities, playing highly important roles in the development, activation and regulation of the immune system and are also related to cancerous cells proliferation. Consequently LPLs or their receptors have become attractive targets for developing drugs specially in the treatment of cancers. Then the development of new synthetic methods for the preparation of LPLs is a challenging problem because the elucidation of the mechanistic details involved in the enzymological, cell-biological and membrane–biophysical roles of LPLs relies obviously on the availability of structurally diverse compounds. We will focus our attention on the chemical and enzymatic synthesis of LPLs and on the biological activity in particular of three LPLs, namely 2-lysophosphatidylcholine (2–LPC), lysophosphatidic acid (LPA) and sphingosine– 1–phosphate (S1P).
Export Options
About this article
Cite this article as:
D’Arrigo Paola and Scotti Massimo, Lysophospholipids: Synthesis and Biological Aspects, Current Organic Chemistry 2013; 17 (8) . https://dx.doi.org/10.2174/1385272811317080007
DOI https://dx.doi.org/10.2174/1385272811317080007 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
University of Kentucky Sanders-Brown Healthy Brain Aging Volunteers: Donor Characteristics, Procedures and Neuropathology
Current Alzheimer Research Microparticles: A Pivotal Nexus in Vascular Homeostasis and Disease
Current Clinical Pharmacology Arrhythmias and Left Ventricular Hypertrabeculation/Noncompaction
Current Pharmaceutical Design Choice of Treatment with Antidepressants: Influencing Factors
Current Pharmaceutical Design Optimized Turmeric Extracts have Potent Anti-Amyloidogenic Effects
Current Alzheimer Research Transbronchial Needle Aspiration (TBNA): Past Present and Future
Current Respiratory Medicine Reviews Drug-Lipid Membrane Interaction Mechanisms Revealed Through Molecular Simulations
Current Physical Chemistry Effect of Rosuvastatin on Non-alcoholic Steatohepatitis in Patients with Metabolic Syndrome and Hypercholesterolaemia: A Preliminary Report
Current Vascular Pharmacology The Measurement of the QT Interval
Current Cardiology Reviews Selection of Antithrombotic Therapy in Patients with Atrial Fibrillation and Percutaneous Coronary Intervention
Current Pharmaceutical Design Insulin Resistance in the Early Stages of Renal Failure: Implications for Cardiovascular Risk
Current Diabetes Reviews The Applications of Biomarkers in Early Clinical Drug Development to Improve Decision-Making Processes
Current Clinical Pharmacology Inflammation as a Therapeutic Target for Various Deadly Disorders: A Review
Current Drug Targets Imidazoline Receptor Agonists for Managing Hypertension May Hold Promise for Treatment of Intracerebral Hemorrhage
Current Molecular Medicine Sinus Node If Channel Inhibition – A New Therapeutic Approach to Heart Rate Lowering
Current Drug Therapy Rho Kinase: An Important Mediator of Atherosclerosis and Vascular Disease
Current Pharmaceutical Design Psychotropics and Methadone in Acquired Long QT Syndrome
Current Psychopharmacology High Density Lipoprotein Associated Paraoxonase1 Activity in Relation to Oxidative Stress in CAD Patients
Current Cardiology Reviews Guidelines and their Implementation: A Discussion Document Focused on the Best Approaches to Drive Improvement
Vascular Disease Prevention (Discontinued) Nitric Oxide-Mediated Endothelial Dysfunction - Is there Need to Treat?
Current Vascular Pharmacology