Hydrogen sulfide (H2S) has been recognized as one of the three important gasotransmitters along with nitric oxide (NO) and
carbon monoxide (CO). H2S plays regulatory roles in the cardiovascular system (CV), central nervous system (CNS), respiratory system,
gastrointestinal system, and endocrine system. The study to understand its molecular mechanism is still ongoing. Current methods for the
detection of H2S include chromatographic methods, electrochemical methods, and colorimetric/fluorometric methods. Fluorescent sensors
and probes are especially important in modern analysis due to their high sensitivity, which can provide nanomolar detection; their
compatibility with high-throughput screening (HTS), which allows for rapid assessment; and their applicability in live cell bioimaging,
which allows real-time detection/observation. This review focuses on strategies used in designing fluorescent sensors and probes for H2S
and their applications.