Recombinant Protein Based Therapeutics for IPF

Author(s): Joseph M. Parker, Michael S. Kramer, Lynne A. Murray

Journal Name: Inflammation & Allergy - Drug Targets (Discontinued)
Formerly Current Drug Targets - Inflammation & Allergy

Volume 12 , Issue 2 , 2013


Abstract:

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, irreversible, and usually fatal interstitial lung disease of unknown cause [1, 2]. The aetiology of IPF is unknown, although identified risk factors for IPF include cigarette smoking, environmental exposures, microbial agents, age, male gender and gastroesophageal reflux disease (GERD). Genetic factors may also play a role in the aetiology of IPF as familial cases of IPF are described in approximately 5% of patients with IPF [2]. Nothing has shown significant anti-fibrotic activity in IPF patients and due to this high unmet medical need, numerous therapeutics are currently under clinical investigation. In this review, we shall focus on recombinant protein based approaches for the treatment of IPF, with a particular focus on pathophysiology of lung fibrosis using the bleomycin mouse model.

Keywords: Bleomycin, epithelium, fibroblast, lung fibrosis, macrophage.

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Article Details

VOLUME: 12
ISSUE: 2
Year: 2013
Published on: 03 April, 2013
Page: [109 - 123]
Pages: 15
DOI: 10.2174/1871528111312020005
Price: $65

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