Lipoxygenase: An Emerging Target for Stroke Therapy

Title:Lipoxygenase: An Emerging Target for Stroke Therapy

Volume: 12 Issue: 2

Author(s): Klaus van Leyen

Affiliation:

Keywords: Ischemic stroke, neuroprotection, oxidative stress, eicosanoid, lipoxygenase, arachidonic acid cascade.

Abstract: Neuroprotection as approach to stroke therapy has recently seen a revival of sorts, fueled in part by the continuing necessity to improve acute stroke care, and in part by the identification of novel drug targets. 12/15- Lipoxygenase (12/15-LOX), one of the key enzymes of the arachidonic acid cascade, contributes to both neuronal cell death and vascular injury. Inhibition of 12/15-LOX may thus provide multifactorial protection against ischemic injury. Targeting 12/15-LOX and related eicosanoid pathways is the subject of this brief review.

Cite this article as:

Leyen Klaus van, Lipoxygenase: An Emerging Target for Stroke Therapy, CNS & Neurological Disorders - Drug Targets 2013; 12 (2) . https://dx.doi.org/10.2174/18715273112119990053