Treatment with statins represents an essential component both of primary and secondary cardiovascular prevention strategies.
However, a proportion of patients cannot reach low-density lipoprotein cholesterol (LDL-C) targets with the highest tolerable dose of a
potent statin or is intolerant to statins. Several treatment options are available for these patients. Colesevelam is a relatively new bile acid
sequestrant that decreases serum LDL-C levels. Moreover, colesevelam improves glycemic control and seems to be well-tolerated, at
least in short-term studies. Therefore, colesevelam seems to be a useful tool for the management of high-risk patients who cannot achieve
LDL-C targets with monotherapy with a potent statin.
Keywords: Colesevelam, statin intolerance, glycemic control, multifactorial intervention, type 2 diabetes mellitus.
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