The Physiology and Pathophysiology of a Novel Angiotensin Receptor-binding Protein ATRAP/Agtrap

Author(s): Kouichi Tamura, Hiromichi Wakui, Akinobu Maeda, Toru Dejima, Masato Ohsawa, Kengo Azushima, Tomohiko Kanaoka, Sona Haku, Kazushi Uneda, Shin-ichiro Masuda, Koichi Azuma, Atsu-ichiro Shigenaga, Yuichi Koide, Yuko Tsurumi-Ikeya, Miyuki Matsuda, Yoshiyuki Toya, Yasuo Tokita, Akio Yamashita, Satoshi Umemura

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 17 , 2013

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The Ang II type 1 receptor (AT1R)-associated protein (ATRAP/Agtrap) is a molecule specifically interacting with the carboxyl- terminal domain of AT1R. The results of in vitro studies showed that ATRAP suppresses Ang II-mediated pathological responses in cardiovascular cells by promoting AT1R internalization. With respect to the tissue distribution and regulation of ATRAP expression in vivo, ATRAP is broadly expressed in many tissues as is AT1R. Accumulating evidence indicates that a tissue-specific regulatory balancing of ATRAP and AT1R expression may be involved in the modulation of AT1R signaling at local tissue sites and also in the pathophysiology of hypertension and its associated end-organ injury. Furthermore, the activation of ATRAP in transgenic-models inhibited inflammatory vascular remodeling and cardiac hypertrophy in response to Ang II stimulation. These results suggest the clinical potential benefit of an ATRAP activation strategy in the treatment of hypertension and related organ injury.

Keywords: Gene expression/regulation, hypertension, receptor internalization, receptor signaling, renin-angiotensin system, target organ injury.

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Article Details

Year: 2013
Published on: 02 April, 2013
Page: [3043 - 3048]
Pages: 6
DOI: 10.2174/1381612811319170010
Price: $65

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