A Mild and Green Method for the N-BOC Protection of Amines without Assistant of Catalyst Under Solvent-free Conditions

Author(s): Mohammad Majid Mojtahedi, Nina Niknejad, Hojat Veisi

Journal Name: Letters in Organic Chemistry

Volume 10 , Issue 2 , 2013

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A facile, green and versatile method for the Boc protection of amines has been developed by a treatment with (Boc)2O without any additive at room temperature. The method is general for the preparation of N-Boc derivatives of aliphatic (acyclic and cyclic), aromatic, and heteroaromatic amines; primary and secondary amines. The advantages of this method are green, simplicity, short reaction times and excellent yields.

Keywords: N-BOC protection, green, catalyst-free, solvent-free

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Article Details

Year: 2013
Published on: 31 March, 2013
Page: [121 - 125]
Pages: 5
DOI: 10.2174/1570178611310020010

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PDF: 263