PTD/CPP Peptide-Mediated Delivery of siRNAs

Author(s): Asaf Presente, Steven F. Dowdy

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 16 , 2013

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Abstract:

siRNA-induced RNA Interference (RNAi) responses have great potential to treat human disease; however, siRNAs are highly charged macromolecules with no ability to enter cells and require a delivery agent. Peptide Transduction Domains (PTDs), also called Cell Penetrating Peptides (CPPs), are delivery peptides with the potential to deliver macromolecular peptides, proteins and siRNAs into cells. Here we discuss the multitude of ways that PTDs/CPPs have been utilized to deliver siRNAs from direct conjugates to complex nanoparticles. PTD/CPP-mediated siRNA delivery has come a long way and has great potential to address the siRNA delivery problem.

Keywords: PTD, CPP, siRNA, RNAi, nanoparticles, cell deliverY, macropinocytosis

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Article Details

VOLUME: 19
ISSUE: 16
Year: 2013
Published on: 27 March, 2013
Page: [2943 - 2947]
Pages: 5
DOI: 10.2174/1381612811319160008
Price: $65

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