NSAIDs are the most commonly prescribed category of drugs for the treatment of musculoskeletal pain and inflammation
associated with many conditions. Topical administration of these drugs is always the best choice since adverse
effects occur commonly with systemic NSAID therapy.
Colloidal drug delivery systems (CDDS) are interesting systems, which are able to improve the duration of drug residence
in the skin and to allow an achievable drug sustained and controlled release compared to conventional topical formulations.
This review focuses on micro and nanoemulsions, vesicular carriers and nanoparticles as novel high efficiency delivery
systems of NSAIDs in topical applications.