Ischemic stroke is the leading cause of mortality and morbidity worldwide for which the assemblage of therapeutic
interventions has remained outstandingly limited. Several new insights into the causes of neuronal death during
ischemic event have led to the identification of some important novel targets for intervention. This article highlights some
of the promising protein targets, which are in the validation process and have the potential to get translated into viable
neurotherapeutics against ischemic stroke.
Keywords: Ischemic stroke, therapeutic targets, excitotoxicity, NADPH oxidase, inflammation, MHC-I, neuroplasticity
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