Genome-Wide Integrated Analyses of Androgen Receptor Signaling in Prostate Cancer Based on High-Throughput Technology

Author(s): Kuniko Horie-Inoue, Satoshi Inoue

Journal Name: Current Drug Targets

Volume 14 , Issue 4 , 2013

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The androgen receptor (AR) is a steroid hormone receptor that functions as a ligand-dependent transcriptional factor, which plays a key role in the development and progression of prostate cancer. Recent advancement in highthroughput technologies including microarrays and deep-sequencing provides unbiased genome-wide knowledge on the AR signaling including datasets for androgen-regulated gene expression and genomic binding sites for AR. In the present review, we will briefly summarize the main features of the AR signaling as well as the individual AR target genes identified by the integration of multiple datasets in prostate cancer. Cap analysis gene expression (CAGE) is also featured as a unique transcriptome method, which particularly determines the androgen-dependent transcription start points in prostate cancer.

Keywords: Androgen receptor, cap analysis gene expression, chromatin immunoprecipitation, prostate cancer

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Article Details

Year: 2013
Page: [472 - 480]
Pages: 9
DOI: 10.2174/1389450111314040008
Price: $65

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PDF: 14