Title:Development and Optimization of Hydroxyapatite-Ofloxacin Implants for Possible Bone Delivery in Osteomyelitis Treatment
VOLUME: 10 ISSUE: 2
Author(s):Amit Kumar Nayak, M. Saquib Hasnain and Jadupati Malakar
Affiliation:Department of Pharmaceutical Chemistry, Shivdan Singh Institute of Technology and Management, Aligarh-202002, U.P., India.
Keywords:Hydroxyapatite, Ofloxacin, Implant, Drug delivery, Optimization, Osteomyelitis
Abstract:The present study deals with preparation, optimization and in-vitro drug release study of hydroxyapatite (HAp)-
ofloxacin for bone-implantable delivery in osteomyelitis treatment. The effect of drug amount added, and orthophosphoric
acid addition rate as process parameters on the drug loading into HAp-system by precipitation method was optimized by
using 32 factorial design. The response surface methodology utilizing polynomial equation was used to search for optimal
drug loading into HAp-system. The responses observed coincided well with the predicted values obtained through optimization
technique. HAp-ofloxacin bone-implants were manufactured using synthesized HAp-ofloxacin composite powders
and 2 % w/v aqueous solution of sodium alginate was used as binder. Characterization of the delivery system was done by
FTIR spectroscopy. The in-vitro ofloxacin release from optimized HAp-ofloxacin bone-implants was slow and sustained
over 10 weeks. The drug release pattern was correlated well with Korsmeyer-Peppas model and was followed by Fickian
(diffusional) release mechanism.
