Development and Optimization of Hydroxyapatite-Ofloxacin Implants for Possible Bone Delivery in Osteomyelitis Treatment

Author(s): Amit Kumar Nayak, M. Saquib Hasnain, Jadupati Malakar

Journal Name: Current Drug Delivery

Volume 10 , Issue 2 , 2013

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The present study deals with preparation, optimization and in-vitro drug release study of hydroxyapatite (HAp)- ofloxacin for bone-implantable delivery in osteomyelitis treatment. The effect of drug amount added, and orthophosphoric acid addition rate as process parameters on the drug loading into HAp-system by precipitation method was optimized by using 32 factorial design. The response surface methodology utilizing polynomial equation was used to search for optimal drug loading into HAp-system. The responses observed coincided well with the predicted values obtained through optimization technique. HAp-ofloxacin bone-implants were manufactured using synthesized HAp-ofloxacin composite powders and 2 % w/v aqueous solution of sodium alginate was used as binder. Characterization of the delivery system was done by FTIR spectroscopy. The in-vitro ofloxacin release from optimized HAp-ofloxacin bone-implants was slow and sustained over 10 weeks. The drug release pattern was correlated well with Korsmeyer-Peppas model and was followed by Fickian (diffusional) release mechanism.

Keywords: Hydroxyapatite, Ofloxacin, Implant, Drug delivery, Optimization, Osteomyelitis

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Article Details

Year: 2013
Published on: 21 March, 2013
Page: [241 - 250]
Pages: 10
DOI: 10.2174/1567201811310020008
Price: $65

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