Title:Design and Evaluation of Matrix Diffusion Controlled Transdermal Patches of Coumarin
VOLUME: 10 ISSUE: 2
Author(s):S. Lakshmana Prabu, S. Thiyagarajan and T.N.K. Suriyaprakash
Affiliation:Department of Pharmaceutical Technology, Anna University of Technology-Tiruchirappalli, Tiruchirappalli 620 024, Tamil Nadu, India.
Keywords:Coumarin, Eudragit RL, Eudragit RS, Release studies, Transdermal patch
Abstract:The aim of the present investigation was to prepare coumarin matrix transdermal systems using the combinations
of Eudragit RL-100/Eudragit RS-100. The formulations were evaluated for various physicochemical properties
(thickness, weight variation, drug content uniformity, moisture content and water absorption uptake), in vitro release studies,
in vitro skin permeation studies and skin irritation studies. In vitro skin permeation and skin irritation studies were
carried out on rat skin and rabbit respectively. The drug–polymer interaction results revealed no interaction between the
drug and the polymers. Drug content uniformity of the patches was found more than 98%. Variations in drug permeation
profiles were observed among the formulations. From the results concluded that coumarin can be formulated into the
transdermal matrix type patches to overcome the first pass effect, reduced frequency of administration of coumarin and
sustain its release characteristics; the polymeric composition Eudragit RL and Eudragit RS (1:1) with 1mL of ethanol was
found to be the best choice for the formulation of transdermal patches of coumarin among the formulation studied.
