Periodontal diseases are common inflammatory conditions of the supporting apparatus of the teeth which lead to early tooth
loss. This review discusses the evidence for a role of reactive oxygen species in inducing periodontal tissue damage and focuses on recent
evidence showing increased local and systemic alterations in the redox balance of periodontitis. An appraisal of the methods for analysis
of oxidative stress in periodontal disease research is provided, showing an increase in oxidative stress measures and oxidative damage
fingerprints detected in studies investigating periodontitis cases compared to healthy controls. Hypotheses on the relationships between
oxidative stress and inflammatory responses and on the role of redox status in periodontal medicine are discussed. Finally, the review
provides an overview of possible intervention pathways for the use of antioxidants as adjuncts to mechanical biofilm removal for the
treatment of periodontitis.