Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by marked atrophy of cortex
and loss of cortical and subcortical neurons. At least two Casein Kinase 1 isoforms have been implicated in the pathogenesis
of AD. The ligand-based virtual screening (LBVS) technique uses the information of a set of actives, focusing on
the activity of this group of molecules against the desired target. Generally, this type of technique is used when there is no
information on the three dimensional structure of the target. However, the use of LBVS allied with three-dimensional information
of the protein binding site provides a more accurate screening, since the information of the active site is taken
into account during the analysis of results.