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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Riboflavin Analogs as Antiinfectives: Occurrence, Mode of Action, Metabolism and Resistance

Author(s): Danielle Biscaro Pedrolli, Frank Jankowitsch, Julia Schwarz, Simone Langer, Shinobu Nakanishi, Eva Frei and Matthias Mack

Volume 19, Issue 14, 2013

Page: [2552 - 2560] Pages: 9

DOI: 10.2174/1381612811319140006

Price: $65

Abstract

Antimetabolites are molecules, which are structurally similar to molecules needed to carry out primary metabolic reactions. The inhibitory activity of an antimetabolite depends on its successful competition with the natural substrate, ligand, modulator or cofactor of a given biomolecule. Antimetabolites are indispensable as molecular tools in order to understand biological processes. Beyond that, antimetabolites have a large variety of applications in the pharmaceutical and food industries. The identification of the structural riboflavin (vitamin B2) analog roseoflavin in Streptomyces davawensis demonstrates that anti-vitamins/cofactor analogs may serve as lead structures for the development of novel antibiotics. The latter is supported by the recent finding that roseoflavin had a profound inhibiting effect on the growth and infectivity of the human bacterial pathogen Listeria monocytogenes at very low concentrations. Roseoflavin is studied in our laboratory as a model compound. We investigate the biosynthesis, the possible large-scale production, the metabolization, the mechanism of action and the resistance mechanism of the producer organism in order to pave the way for the structured analysis of other vitamin analogs yet to be discovered. These compounds hopefully will help to replenish the arsenal of antimicrobials urgently needed to fight multiresistant bacterial pathogens.

Keywords: Antimetabolites, riboflavin (vitamin B2) analogs, flavoenzymes, FMN riboswitches, roseoflavin, 8-demethyl-8-amino-riboflavin, Streptomyces davawensis


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