Abstract
Cardiac hypertrophy/remodeling manifests as a critical condition which may likely predispose to the risk of fatal heart failure and multiple organ dysfunction if not efficiently addressed, as a result of irreversible neuroendocrine, autonomic and immune system imbalances. Undeniably, the over-excitation of sympathetic and/or the breakdown of central parasympathetic tone play a significant role to be the basis of the persistent immune activation in chronic heart failure (CHF) which, to a certain extent, is primed by inflammatory reactions in the Central Nervous System. Moreover, till today, the clinical management of CHF seeks the identification of molecularly targeted drugs in comparison to those considered so far. This review focuses on the possible neuroimmune-mediated pathways involved in CHF and throws light on the current therapeutic strategies.
Keywords: Autonomic system, chronic heart failure, inflammatory mediators.
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title:Neuroimmune Activation in Chronic Heart Failure
Volume: 13 Issue: 1
Author(s): Giorgio Fiore, Patrizia Suppress, Vincenzo Triggiani, Francesco Resta and Carlo Sabba
Affiliation:
Keywords: Autonomic system, chronic heart failure, inflammatory mediators.
Abstract: Cardiac hypertrophy/remodeling manifests as a critical condition which may likely predispose to the risk of fatal heart failure and multiple organ dysfunction if not efficiently addressed, as a result of irreversible neuroendocrine, autonomic and immune system imbalances. Undeniably, the over-excitation of sympathetic and/or the breakdown of central parasympathetic tone play a significant role to be the basis of the persistent immune activation in chronic heart failure (CHF) which, to a certain extent, is primed by inflammatory reactions in the Central Nervous System. Moreover, till today, the clinical management of CHF seeks the identification of molecularly targeted drugs in comparison to those considered so far. This review focuses on the possible neuroimmune-mediated pathways involved in CHF and throws light on the current therapeutic strategies.
Export Options
About this article
Cite this article as:
Fiore Giorgio, Suppress Patrizia, Triggiani Vincenzo, Resta Francesco and Sabba Carlo, Neuroimmune Activation in Chronic Heart Failure, Endocrine, Metabolic & Immune Disorders - Drug Targets 2013; 13 (1) . https://dx.doi.org/10.2174/1871530311313010009
DOI https://dx.doi.org/10.2174/1871530311313010009 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Trafficking of Neuronal Two Pore Domain Potassium Channels
Current Neuropharmacology Nano Traditional Chinese Medicine: Current Progresses and Future Challenges
Current Drug Targets Inhibitory Effect on Replicative DNA Polymerases, Human Cancer Cell Proliferation, and In Vivo Anti-Tumor Activity by Glycolipids from Spinach
Current Medicinal Chemistry Interrelation Between Protein Synthesis, Proteostasis and Life Span
Current Genomics Circulating Biomarkers of Collagen Metabolism and Prognosis of Heart Failure with Reduced or Mid-Range Ejection Fraction
Current Pharmaceutical Design Vascular microRNAs
Current Drug Targets Efficacy and Cardiovascular Safety of Insulins
Current Drug Safety Cardiovascular Effects of Green Tea Catechins: Progress and Promise
Recent Patents on Cardiovascular Drug Discovery Meet Our Editorial Board Member
Current Drug Safety Troponin in Newborns and Pediatric Patients
Cardiovascular & Hematological Agents in Medicinal Chemistry Methotrexate: A Drug of the Future in Ulcerative Colitis?
Current Drug Targets Scorpion Toxin Polyptides as Therapeutic Agents: An Overview
Protein & Peptide Letters Intracellular Calcium Homeostasis and Kidney Disease
Current Medicinal Chemistry Molecular Bases of Liver Cancer Refractoriness to Pharmacological Treatment
Current Medicinal Chemistry Microvesicles-mediated Cell Communication in Pulmonary Arterial Hypertension
Current Medicinal Chemistry Sodium-glucose Cotransporter 2 Inhibitors: The Impact on Development and Progression of Heart Failure
Cardiovascular & Hematological Disorders-Drug Targets Anesthetic-induced Myocardial Conditioning: Molecular Fundamentals and Scope
Current Medicinal Chemistry Potential Use of Vanadium Compounds in Therapeutics
Current Medicinal Chemistry Phosphodiesterase-5 Inhibitors: Future Perspectives
Current Pharmaceutical Design Fish and Apoptosis: Studies in Disease and Pharmaceutical Design
Current Pharmaceutical Design