Diabetes and Chronic Heart Failure: From Diabetic Cardiomyopathy to Therapeutic Approach

Author(s): A. Dei Cas, V. Spigoni, V. Ridolfi, M. Metra

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders

Volume 13 , Issue 1 , 2013

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Diabetes and chronic heart failure are interrelated conditions with major medical and economic impact that have to be treated as a distinct entity. Several pathological mechanisms have been investigated and proposed to explain the structural and functional changes associated with diabetic cardiomyopathy. These mechanisms are likely to act synergically and may potentiate one the other. This review outlines recent advances in the pathophysiological mechanisms implicated in the development and progression of diabetic cardiomyopathy and in current therapeutic strategies.

Keywords: Chronic heart failure, diabetes mellitus, diabetic cardiomyopathy, molecular mechanisms, structural alteration, therapy.

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Article Details

Year: 2013
Published on: 12 March, 2013
Page: [38 - 50]
Pages: 13
DOI: 10.2174/1871530311313010006

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