A series of new of 2-furano-4(3H)-quinazolinone derivatives 5 (a-t) were synthesized. The compounds were
characterized by their IR, 1H NMR, 13C NMR, and Mass spectral data. The antimicrobial activity of newly anthranilic
acid-based compounds against various bacteria; S. aureus, Salmonella enterica, Vibrio cholerae, Bacillus subtilis, Proteus
mirabili, Escherichia coli V517, Mycobacterium smegmatics, Pseudomonas aeruginosa and fungi; C. albicans, were
evaluated with ampicillin and amphotericin B as standards. All compounds were also evaluated for antibacterial activity
against R. solanacearum along with Kocide 3000 as a commercialized reference. Compounds 5d, 5g, 5j, 5l, 5q, 5r, 5s,
and 5t exhibited good potential as antimicrobial.