Synthesis and Characterization of Clubbed Thiazolidin-4-one, Quinoline and Barbitone Derivatives as a Potent Antimicrobial Agents

Author(s): Nisheeth Chhotalal Desai, Hitesh Mansukhbhai Satodiya, Kiran Mavjibhai Rajpara, Vivek Vishnuprasad Joshi, Hasit Vinodray Vaghani

Journal Name: Letters in Drug Design & Discovery

Volume 10 , Issue 4 , 2013

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In the present investigation, it was of interest to synthesized some new derivatives of pyrimidine- 2,4,6(1H,3H,5H)-trione moiety incorporated with different biologically active pharmacophores such as thiazolidin-4- one, barbitone and 2-chloroquinoline-3-carbaldehyde. The structures of synthesized compounds were elucidated by IR, 1H NMR, 13C NMR, and mass spectral data. Antimicrobial screening of title compounds were examined against Grampositive bacteria (Staphylococcus aureus and Streptococcus pyogenes), Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), and three fungal species (Candida albicans, Aspergillus niger, and Aspergillus clavatus) by serial broth dilution method. Compounds 6b, 6e, 6f and 6h were associated with considerably higher antibacterial and antifungal activities.

Keywords: Barbitone, Quinoline, Thiazolidin-4-one

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Article Details

Year: 2013
Published on: 12 March, 2013
Page: [335 - 342]
Pages: 8
DOI: 10.2174/1570180811310040007
Price: $65

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