Title:Synthesis and Characterization of Clubbed Thiazolidin-4-one, Quinoline and Barbitone Derivatives as a Potent Antimicrobial Agents
VOLUME: 10 ISSUE: 4
Author(s):Nisheeth Chhotalal Desai, Hitesh Mansukhbhai Satodiya, Kiran Mavjibhai Rajpara, Vivek Vishnuprasad Joshi and Hasit Vinodray Vaghani
Affiliation:Division of Medicinal Chemistry, Department of Chemistry, Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar 364 002, India.
Keywords:Barbitone, Quinoline, Thiazolidin-4-one
Abstract:In the present investigation, it was of interest to synthesized some new derivatives of pyrimidine-
2,4,6(1H,3H,5H)-trione moiety incorporated with different biologically active pharmacophores such as thiazolidin-4-
one, barbitone and 2-chloroquinoline-3-carbaldehyde. The structures of synthesized compounds were elucidated by IR, 1H
NMR, 13C NMR, and mass spectral data. Antimicrobial screening of title compounds were examined against Grampositive
bacteria (Staphylococcus aureus and Streptococcus pyogenes), Gram-negative bacteria (Escherichia coli and
Pseudomonas aeruginosa), and three fungal species (Candida albicans, Aspergillus niger, and Aspergillus clavatus) by
serial broth dilution method. Compounds 6b, 6e, 6f and 6h were associated with considerably higher antibacterial and
antifungal activities.
