In search for the new antimicrobial agents owing to drug resistant bacteria and fungi, a series of rationally designed
aza analogs of flavones has been designed and synthesized. The design of the analogs involved incorporation of
quinolone nucleus within the flavone framework keeping in view the antimicrobial potential of both the classes. The series
of compounds was evaluated for the antibacterial and antifungal activity against 3 Gram negative bacterial strains; E.
coli (MTCC 82), S. typhi (MTCC 1251), P. aeruginosa (MTCC 2642), 2 gram positive bacterial strains B. subtilis (MTCC
2451), S. aureus (MTCC 96) and 2 pathogenic fungal strains, C. albicans (MTCC 3018), C. tropicalis (MTCC). The results
of the antimicrobial evaluation clearly indicated the influence of the electronic factors linked with the aryl ring at the
2nd position with compounds bearing methoxy substitutents exhibiting significant antimicrobial profile as compared to the
compounds bearing deactivating groups. The influence of placement of bicyclic, heteroaryl and bicyclic heteroaryl ring at
the 2nd position of the analogs was also observed.
Keywords: Flavones, Quinolones, Antimicrobial activity, Strains, Antibacterial, Antifungal
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