This review is focused on the role of Focal Adhesion Kinase (FAK) signaling in cancer stem cells. The recent data
demonstrate the important role of FAK in cancer stem cell proliferation, differentiation, motility, and invasion. We showed recently that
the transcription factor Nanog binds the FAK promoter and up-regulates FAK expression, and that FAK binds Nanog and phosphorylates
it. This review discusses the interaction of FAK, Nanog, Oct-3/4, and Sox-2 signaling pathways that are critical for the regulation of
cancer stem cells. The cross-linked signaling of FAK with p53 and Nanog signaling in cancer stem cell and function and targeted
therapeutics approaches are discussed.