Abstract
In view of the large libraries of acetylcholinesterase inhibitors (AChEIs) that are now being handled in organic synthesis, the identification of drug biological activity is advisable prior to synthesis and this can be achieved by employing predictive biological property methods. In this sense, Quantitative Structure–Activity Relationships (QSAR) or docking approaches have emerged as promising tools. The intention of this review is to summarize the present knowledge concerning computational predictions of AChEIs and AChE.
Keywords: Acetylcholinesterase inhibitors, computational predictions, docking approaches, molecular modeling, QSAR
Central Nervous System Agents in Medicinal Chemistry
Title:Acetylcholinesterase Inhibitors from QSAR Point of View: How Close are We?
Volume: 13 Issue: 1
Author(s): Anuradha Sharma and Poonam Piplani
Affiliation:
Keywords: Acetylcholinesterase inhibitors, computational predictions, docking approaches, molecular modeling, QSAR
Abstract: In view of the large libraries of acetylcholinesterase inhibitors (AChEIs) that are now being handled in organic synthesis, the identification of drug biological activity is advisable prior to synthesis and this can be achieved by employing predictive biological property methods. In this sense, Quantitative Structure–Activity Relationships (QSAR) or docking approaches have emerged as promising tools. The intention of this review is to summarize the present knowledge concerning computational predictions of AChEIs and AChE.
Export Options
About this article
Cite this article as:
Sharma Anuradha and Piplani Poonam, Acetylcholinesterase Inhibitors from QSAR Point of View: How Close are We?, Central Nervous System Agents in Medicinal Chemistry 2013; 13 (1) . https://dx.doi.org/10.2174/1871524911313010009
DOI https://dx.doi.org/10.2174/1871524911313010009 |
Print ISSN 1871-5249 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6166 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Resveratrol and Cancer Treatment: Is Hormesis a Yet Unsolved Matter?
Current Pharmaceutical Design Meet Our Editorial Board Member
Current Alzheimer Research Efficacy of Duloxetine in Patients with Chronic Pain Conditions
Current Drug Therapy Current Trends in the Development of New Antidepressants
Current Medicinal Chemistry B Cell Depletion in Systemic Vasculitis
Current Immunology Reviews (Discontinued) Strategies to Reduce Oxidative Stress in Glaucoma Patients
Current Neuropharmacology Conformational Changes of the Protein Domains Upon Binding with Carbon Nanotubes Studied by Molecular Dynamics Simulations
Current Physical Chemistry CD26 / Dipeptidyl Peptidase IV: A Regulator of Immune Function and a Potential Molecular Target for Therapy
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Current Updates on Bone Grafting Biomaterials and Recombinant Human Growth Factors Implanted Biotherapy for Spinal Fusion: A Review of Human Clinical Studies
Current Drug Delivery Humanin Nanoparticles for Reducing Pathological Factors Characteristic of Age-Related Macular Degeneration
Current Drug Delivery Neuroprotective Properties of Peroxisome Proliferator-Activated Receptor Alpha (PPARα) and its Lipid Ligands
Current Medicinal Chemistry Outcome-Dependent Global Similarity Analysis of Imbalanced Core Signaling Pathways in Ischemic Mouse Hippocampus
CNS & Neurological Disorders - Drug Targets Astrocyte Signaling and Multiple Sclerosis
Current Signal Transduction Therapy Intravenous Immunoglobulin Reduces Tau Pathology and Preserves Neuroplastic Gene Expression in the 3xTg Mouse Model of Alzheimer`s Disease
Current Alzheimer Research Concentrations of Cd, Cu, Pb and Zn in Blood Serum of Cancer Patients and Comparison with Healthy Person by Atomic Absorption Spectrometry
Current Analytical Chemistry Past, Present, and Future of Targeting Ras for Cancer Therapies
Mini-Reviews in Medicinal Chemistry Genetics of Anxiety Disorders - Status Quo and Quo Vadis
Current Pharmaceutical Design A Randomized, Double-Blind, Placebo-Controlled, 16-Week Study of the H<sub>3</sub> Receptor Antagonist, GSK239512 as a Monotherapy in Subjects with Mild-to-Moderate Alzheimer’s Disease
Current Alzheimer Research Cardiac Toxicities of Antiangiogenic Therapies
Current Angiogenesis (Discontinued) Phenyl Substituted Thiazole Linked 1, 2, 4-triazole Derivatives: Synthesis and Their Biological Evaluation
Letters in Organic Chemistry