Mechanisms in the Bed Nucleus of the Stria Terminalis Involved in Control of Autonomic and Neuroendocrine Functions: A Review

Author(s): Carlos C. Crestani, Fernando H.F. Alves, Felipe V. Gomes, Leonardo B.M. Resstel, Fernando M.A. Correa, James P. Herman

Journal Name: Current Neuropharmacology

Volume 11 , Issue 2 , 2013

Become EABM
Become Reviewer
Call for Editor


The bed nucleus of the stria terminalis (BNST) is a heterogeneous and complex limbic forebrain structure, which plays an important role in controlling autonomic, neuroendocrine and behavioral responses. The BNST is thought to serve as a key relay connecting limbic forebrain structures to hypothalamic and brainstem regions associated with autonomic and neuroendocrine functions. Its control of physiological and behavioral activity is mediated by local action of numerous neurotransmitters. In the present review we discuss the role of the BNST in control of both autonomic and neuroendocrine function. A description of BNST control of cardiovascular and hypothalamus-pituitary-adrenal axisactivity at rest and during physiological challenges (stress and physical exercise) is presented. Moreover, evidence for modulation of hypothalamic magnocellular neurons activity is also discussed. We attempt to focus on the discussion of BNST neurochemical mechanisms. Therefore, the source and targets of neurochemical inputs to BNST subregions and their role in control of autonomic and neuroendocrine function is discussed in details.

Keywords: BNST, cardiovascular function, extended amygdala, neurotransmitters, HPA axis, vasopressin, stress and physical exercise

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2013
Published on: 05 March, 2013
Page: [141 - 159]
Pages: 19
DOI: 10.2174/1570159X11311020002
Price: $65

Article Metrics

PDF: 6