Abstract
The management of extensive bone defects in the setting of fracture repair, non-union and revision arthroplasty are challenging problems. The supply of harvestable autologous bone graft is limited, with an associated morbidity, and therefore a need exists for a better solution in large defects. The use of stem cells is an evolving field of research, with different potential applications, ranging from simple injection of cells to tissue engineering using osteogenic cells seeded onto a scaffold.
This systematic review aims to collate the published preclinical and clinical studies investigating the potential use of stem cells for bone repair.Keywords: Bone repair, scaffolds, stem cells, tissue engineering
Current Stem Cell Research & Therapy
Title:Preclinical and Clinical Studies on the Use of Stem Cells for Bone Repair: A Systematic Review
Volume: 8 Issue: 3
Author(s): Anuruthran Ambikaipalan, James Min-Leong Wong and Wasim S. Khan
Affiliation:
Keywords: Bone repair, scaffolds, stem cells, tissue engineering
Abstract: The management of extensive bone defects in the setting of fracture repair, non-union and revision arthroplasty are challenging problems. The supply of harvestable autologous bone graft is limited, with an associated morbidity, and therefore a need exists for a better solution in large defects. The use of stem cells is an evolving field of research, with different potential applications, ranging from simple injection of cells to tissue engineering using osteogenic cells seeded onto a scaffold.
This systematic review aims to collate the published preclinical and clinical studies investigating the potential use of stem cells for bone repair.Export Options
About this article
Cite this article as:
Ambikaipalan Anuruthran, Min-Leong Wong James and S. Khan Wasim, Preclinical and Clinical Studies on the Use of Stem Cells for Bone Repair: A Systematic Review, Current Stem Cell Research & Therapy 2013; 8 (3) . https://dx.doi.org/10.2174/1574888X11308030005
DOI https://dx.doi.org/10.2174/1574888X11308030005 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
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