Piperidin-4-one: The Potential Pharmacophore

Author(s): Shashi Kant Sahu, Bidhyut Kumar Dubey, Avinash C. Tripathi, Mary Koshy, Shailendra K. Saraf

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 4 , 2013

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The piperidin-4-ones have been reported as versatile intermediates. They have been synthesized using a variety of methods, including Mannich reaction and stereoselective synthesis. The piperidin-4-ones have been reported to possess various pharmacological activities, including anticancer and anti HIV activities. The pharmacophore can be suitably modified in order to achieve better receptor interactions and biological activities. The renewed interest in the nucleus has re-established the importance of piperidin-4-ones in medicinal chemistry. The review intends to discuss the current research trends in the synthetic protocols, characterization, stereochemistry and important biological activities of piperidin-4-ones during the last decade.

Keywords: Piperidin-4-one, Mannich reaction, stereochemistry, anticancer, antiviral, antimicrobial, pyridopyrimidinethione, dimethylformamide

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Article Details

Year: 2013
Published on: 28 February, 2013
Page: [565 - 583]
Pages: 19
DOI: 10.2174/1389557511313040009
Price: $65

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