Title:Chronotherapeutic Drug Delivery from Indomethacin Compression Coated Tablets for Early Morning Pain Associated Rheumatoid Arthritis
VOLUME: 10 ISSUE: 1
Author(s):Songa Ambedkar Sunil, Meka Venkata Srikanth, Nali Sreenivasa Rao and Kolapalli Venkata Ramana Murthy
Affiliation:A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India-530003.
Keywords:Compression coated tablet, lag time, in vivo study, Polyethylene oxide, Solid dispersions, Sucrose fatty acid ester
Abstract:As the main intent of delivering maximum concentration of drug available from the dosage form, an oral
compression coated tablet (CCT) was intended to develop with a predetermined lag time of 6 hrs before immediate release
of drug to target circadian rhythms of rheumatoid arthritis. Solid dispersions are promising approach to enhance drug
release, which later will be developed as core tablet formulation and compression coated with polyethylene oxide (PEO
WSR 303). Solid dispersions were formulated with different ratio of drug and carrier (sucrose fatty acid esters 1811) using
solvent evaporation and melt granulation technique, optimized solid dispersion was formulated as core tablet with
different diluents. Optimized core tablet was compression coated with PEO WSR 303 along with a channeling agent
(DCL 21, mannitol, HPMC 5 cps and starch 1500). Lag time before immediate release of drug was markedly dependent
on weight ratios of polymer and channeling agent used, which ranged from 4 to 12 hrs. Optimized solid dispersion (S9)
was used for formulating optimized core tablet formulation (C8). CCT (T8) prepared with core tablet (C8) along with
mannitol provided a lag time of 6 hrs with minimum concentration of channeling agent used, which was also supported
from the permeability study results. Incompatibility and characterization was confirmed from DSC, XRD, FTIR and SEM
studies. Unaltered Cmax and AUC0-t but delayed Tmax following oral ingestion of optimized formulation (T8) to human
volunteers indicated clear lag time before immediate release of drug, which is suitable for treating rheumatoid arthritis
following circadian rhythm.
