Abstract
Fast-dissolving drug-delivery systems were first developed in the late 1970s as an alternative to tablets, capsules, and syrups for pediatric and geriatric patients who experience difficulties swallowing traditional oral solid dosage forms. In response to this need, a variety of orally disintegrating tablet (ODT) formats were commercialized, which disintegrate within 1 min when placed in the mouth without drinking water or chewing. Oral drug delivery technology has improved from conventional dosage forms to modified release dosage forms to ODT to the recent oral disintegrating films (ODF). Oral disintegrating film or strip that employs a water dissolving polymer which allows the dosage form to quickly hydrate by saliva, adhere to mucosa, and disintegrate within a few seconds, dissolve and releases medication for oromucosal absorption when placed on the tongue or oral cavity. Oral strip technology provides an alternate route for drugs with first pass metabolism. This review give details of materials used in ODF, manufacturing aspects, technologies, evaluation tests and marketed products.
Keywords: Oral disintegrating films, Oral strip, Disintegration, Oral cavity, Pediatric Patients, Geriatric Patients
Current Drug Delivery
Title:Comprehensive Review On Oral Disintegrating Films
Volume: 10 Issue: 1
Author(s): T. Nagaraju, R. Gowthami, M. Rajashekar, S. Sandeep, M. Mallesham, D. Sathish and Y. Shravan Kumar
Affiliation:
Keywords: Oral disintegrating films, Oral strip, Disintegration, Oral cavity, Pediatric Patients, Geriatric Patients
Abstract: Fast-dissolving drug-delivery systems were first developed in the late 1970s as an alternative to tablets, capsules, and syrups for pediatric and geriatric patients who experience difficulties swallowing traditional oral solid dosage forms. In response to this need, a variety of orally disintegrating tablet (ODT) formats were commercialized, which disintegrate within 1 min when placed in the mouth without drinking water or chewing. Oral drug delivery technology has improved from conventional dosage forms to modified release dosage forms to ODT to the recent oral disintegrating films (ODF). Oral disintegrating film or strip that employs a water dissolving polymer which allows the dosage form to quickly hydrate by saliva, adhere to mucosa, and disintegrate within a few seconds, dissolve and releases medication for oromucosal absorption when placed on the tongue or oral cavity. Oral strip technology provides an alternate route for drugs with first pass metabolism. This review give details of materials used in ODF, manufacturing aspects, technologies, evaluation tests and marketed products.
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Cite this article as:
Nagaraju T., Gowthami R., Rajashekar M., Sandeep S., Mallesham M., Sathish D. and Shravan Kumar Y., Comprehensive Review On Oral Disintegrating Films, Current Drug Delivery 2013; 10 (1) . https://dx.doi.org/10.2174/1567201811310010016
DOI https://dx.doi.org/10.2174/1567201811310010016 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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