Title:Melatonin and Synthetic Analogs as Antioxidants
VOLUME: 10 ISSUE: 1
Author(s):Sibel Suzen
Affiliation:Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100, Tandogan, Ankara, Turkey.
Keywords:Antioxidant, free radical, melatonin, indole, synthesis
Abstract:Recent studies suggest that overproduction of reactive oxygen and nitrogen species (ROS/RNS), lowered antioxidant
defense of the body. Oxidative stress is damaging to DNA, lipids, proteins and many more vital macromolecules.
Consequences of oxidative stress thought to contribute to the development of a wide range of diseases including
Alzheimer's disease, Parkinson's disease, diabetes, rheumatoid arthritis, neurodegeneration in motor neuron diseases and
many cancer types. Melatonin (MLT) is a powerful antioxidant with a particular role in the protection of nuclear and
mitochondrial DNA. To find an improved antioxidant activity, developments of novel synthetic analogues are under investigation.
These studies may offer a new progress and approach in antioxidant drug development as well as antioxidant
chemistry. Therefore, we have been synthesizing novel MLT derivatives and investigating their antioxidant capacities.
This review gives a brief knowledge about the MLT based analogue indole derivatives as potential antioxidants.
