Melatonin and Synthetic Analogs as Antioxidants

Author(s): Sibel Suzen

Journal Name: Current Drug Delivery

Volume 10 , Issue 1 , 2013

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Recent studies suggest that overproduction of reactive oxygen and nitrogen species (ROS/RNS), lowered antioxidant defense of the body. Oxidative stress is damaging to DNA, lipids, proteins and many more vital macromolecules. Consequences of oxidative stress thought to contribute to the development of a wide range of diseases including Alzheimer's disease, Parkinson's disease, diabetes, rheumatoid arthritis, neurodegeneration in motor neuron diseases and many cancer types. Melatonin (MLT) is a powerful antioxidant with a particular role in the protection of nuclear and mitochondrial DNA. To find an improved antioxidant activity, developments of novel synthetic analogues are under investigation. These studies may offer a new progress and approach in antioxidant drug development as well as antioxidant chemistry. Therefore, we have been synthesizing novel MLT derivatives and investigating their antioxidant capacities. This review gives a brief knowledge about the MLT based analogue indole derivatives as potential antioxidants.

Keywords: Antioxidant, free radical, melatonin, indole, synthesis

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Article Details

Year: 2013
Page: [71 - 75]
Pages: 5
DOI: 10.2174/1567201811310010013
Price: $65

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PDF: 43