Microwave-assisted Suzuki-Miyaura Cross-Coupling of Free (NH) 3-Bromoindazoles

Author(s): Ali Ben-Yahia, Mohammed Naas, Nabil El Brahmi, Said El Kazzouli, Jean-Pierre Majoral, El Mokhtar Essassi, Gerald Guillaumet.

Journal Name: Current Organic Chemistry

Volume 17 , Issue 3 , 2013

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Abstract:

Suzuki-Miyaura cross-coupling of free (NH) indazoles is described. The reactions are carried out under microwave irradiation using various 3-bromoindazoles and boronic acids. Different reaction conditions were investigated and the best results were obtained using Pd(PPh3)4 and Cs2CO3 in a mixture of 1,4-dioxane/EtOH/H2O at 140 °C under microwave irradiation.

Keywords: Suzuki-Miyaura cross-coupling, Free (NH) indazoles, Microwave irradiation, Palladium-mediated cross-coupling, Boronic acids, Sealed vessel, 3-chloroindazole, Indazoles, Cs2CO3, Pyridin-3-ylboronic acid

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Article Details

VOLUME: 17
ISSUE: 3
Year: 2013
Page: [304 - 309]
Pages: 6
DOI: 10.2174/1385272811317030011
Price: $58

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