This review deals with nitrogen oxides (NO, NO2, N2O) and NO derivatives peroxynitrite, peroxynitrous acid
and nitroxyl, in relation to therapeutic effects and toxicity. An important member is NO which plays a multiple role in
physiological action. The derivatives formed from interactions with superoxide are powerful oxidants functioning in toxicity.
Nitroxyl (HNO), a metabolite of hydroxamic acids and hydroxyurea, is involved in the mode of action. Antioxidant
action is discussed, as well as cell signaling. A multifaceted approach to bioaction is recommended.
Keywords: Nitrogen oxides (NO, NO2, N2O), peroxynitrite, hyponitrous acid, nitroxyl, mechanism, bioaction, Antioxidant
action, cell signaling, Down’s syndrome, endothelial dysfunction
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