The present paper describes the design and synthesis of a series of some 2-naphthyloxy derivatives with their
antiamnesic activity using mice as the animal model and piracetam as the reference drug. All the synthesized compounds
were characterized by spectroscopic techniques and were screened for their efficacy as cognition enhancers by elevated
plus maze test and acetylcholinestrase inhibitory assay.
Molecular modeling and docking studies of the selected compounds into the crystal structure of acetylcholinestrase complexed
with functional ligand succinylcholine using GRAMM software was performed in order to predict the affinity and
orientation of the synthesized derivatives at the active site. The binding energy of ligands was calculated using ArgusLab
software. The docking score and hydrogen bonds formed with surrounding amino acids show the good agreement with
predicted binding affinities obtained by molecular docking studies, as verified by acetylcholinestrase activity.
Keywords: Acetycholinesterase inhibition, amnesic activity, arguslab, cognition enhancer, gramm, molecular docking, 2-
naphthyloxy derivatives, amino acids, Computer docking
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