Modulation of Interaction Between Virus and Eukaryotic Host by Exposure to S. aureus Bacterial Soluble Fractions

Author(s): Coralia Bleotu, Gratiela Pircalabioru, Roxana Dragusel, Ioana-Madalina Aldea, Botezatu Anca, Otilia Banu, Grigore Mihaescu, Costin Eugen Cernescu, Carmen Cristina Diaconu

Journal Name: Current Organic Chemistry

Volume 17 , Issue 2 , 2013

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The purpose of this study was to investigate how a viral infection affecting the epithelial cells could be influenced by the presence of the opportunistic Staphylococcus aureus soluble mediators. The viral antigens presence, apoptosis and cytokine profiles of HeLa cells infected with HSV-1 and pre-/postreated with different bacterial soluble fractions were evaluated. Soluble bacterial molecules could modulate HeLa cells functions to prevent the development of viral infection, but later stages of viral infection are less affected by bacterial soluble mediators. The in vitro cooperative action of HSV-1 and of S. aureus soluble fractions modulated the immune response of the infected HeLa cells, mainly by triggering the release of pro-inflammatory cytokines.

Keywords: HSV, S. aureus, Co-infection

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Article Details

Year: 2013
Published on: 19 February, 2013
Page: [137 - 143]
Pages: 7
DOI: 10.2174/1385272811317020009
Price: $65

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