Alterations of Brain Membranes in Schizophrenia: Impact of Phospholipase A2

Author(s): E.L. Schaeffer, W.F. Gattaz, G.P. Eckert

Journal Name: Current Topics in Medicinal Chemistry

Volume 12 , Issue 21 , 2012


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Abstract:

Physiological enzymatic cleavage of membrane phospholipids by phospholipase A2 (PLA2) results in normal levels of phosphomonoester and phosphodiester, by which a normal dopamine neurotransmission is maintained. Data from postmortem tissue and in vivo imaging studies suggest that increased activity of intracellular calcium-independent PLA2 (iPLA2) in the brain of schizophrenic patients might accelerate the breakdown of membrane phospholipids and alter the properties of neuronal membranes, which in turn contributes to a hypodopaminergy. Alterations in PLA2 activity are probably genetically determined and represent a possible pharmacological target for Schizophrenia.

Keywords: schizophrenia, neuroimaging, membrane, phospholipase A2, dopamine

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Article Details

VOLUME: 12
ISSUE: 21
Year: 2012
Published on: 19 February, 2013
Page: [2314 - 2323]
Pages: 10
DOI: 10.2174/1568026611212210004
Price: $65

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