The Clinical Applications of Curcumin: Current State and the Future

Author(s): Xia Fan, Chun Zhang, Dong-bo Liu, Jun Yan, Hua-ping Liang

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 11 , 2013

Become EABM
Become Reviewer


Curcumin is a natural polyphenol product derived from the rhizome of the Curcuma longa. In vivo and in vitro studies have uncovered many important bioactivities of curcumin, such as antioxidant activity, inducing cell apoptosis, inhibiting cell proliferation, anti-cell adhesion and motility, anti-angiogenesis and anti-microbe properties. Based on these functions, curcumin has been used in clinical trials on various inflammatory diseases and cancers. In the future, it will be necessary to focus attention partly on the clinical application of curcumin in neurodegenerative diseases, cardiovascular diseases and diabetes, because many experiments have clarified the potential value of curcumin in these areas. As a diet-derived agent, curcumin has no severe toxicity except for minor gastrointestinal side effects even up to the dosage of 8 grams for 3 months. However, curcumin has a low systemic bioavailability, so it is imperative to improve the bioavailability of curcumin in its clinical application. Many methods, such as adjuvant drug delivery system and structural modification have been demonstrated to have a potential effect.

Keywords: Curcumin, inflammation, cancer, bioavailability, clinical application, polyphenol, Curcuma longa, antioxidant activity, cell apoptosis, anti-angiogenesis

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2013
Page: [2011 - 2031]
Pages: 21
DOI: 10.2174/1381612811319110005

Article Metrics

PDF: 216