Abstract
The interactions between disease processes and the metabolism of therapeutic drugs have not been systematically investigated. Inflammation, with the presence of pro-inflammatory cytokines, affects Phase 1 metabolism, particularly the activity of the CYP isoforms. Inflammatory factors also alter the activity of some Phase 2 enzymes, particularly the sulphotransferases (SULT isoforms) responsible for drug sulphonation and the enzyme pathway involved in the supply of sulphate for this reaction. Being ill may, therefore, in itself make drug metabolism unpredictable.
Keywords: Inflammation, Illness, Sulphation, Drug Metabolism, Xenobiotic, Drug Reactions, SULT, Isoforms, Phase 2, Cytokines, Sulphate
Current Drug Metabolism
Title:Xenobiotic Sulphation and its Variability During Inflammation: a Factor in Adverse Drug Reactions?
Volume: 14 Issue: 3
Author(s): R.H. Waring, R.M. Harris, J.O. Hunter and S.C. Mitchell
Affiliation:
Keywords: Inflammation, Illness, Sulphation, Drug Metabolism, Xenobiotic, Drug Reactions, SULT, Isoforms, Phase 2, Cytokines, Sulphate
Abstract: The interactions between disease processes and the metabolism of therapeutic drugs have not been systematically investigated. Inflammation, with the presence of pro-inflammatory cytokines, affects Phase 1 metabolism, particularly the activity of the CYP isoforms. Inflammatory factors also alter the activity of some Phase 2 enzymes, particularly the sulphotransferases (SULT isoforms) responsible for drug sulphonation and the enzyme pathway involved in the supply of sulphate for this reaction. Being ill may, therefore, in itself make drug metabolism unpredictable.
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Cite this article as:
Waring R.H., Harris R.M., Hunter J.O. and Mitchell S.C., Xenobiotic Sulphation and its Variability During Inflammation: a Factor in Adverse Drug Reactions?, Current Drug Metabolism 2013; 14 (3) . https://dx.doi.org/10.2174/1389200211314030011
DOI https://dx.doi.org/10.2174/1389200211314030011 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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