Gene Transfer and Drug Delivery with Electric Pulse Generators

Author(s): Chenguo Yao, Fei Guo, Chengxiang Li, Caixin Sun

Journal Name: Current Drug Metabolism

Volume 14 , Issue 3 , 2013

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Abstract:

Electroporation is a process that involves a series of intense electric pulses used to overcome the barrier of the cell membrane. The application of an external electric field may result in reversible breakdown of cell membrane. This transient state helps to introduce cells with a variety of different molecules, such as DNA and drug molecules, and is known as the fundamental mechanisms of gene transfer and drug delivery with electric pulses. This paper reviews (1) the utility of electric pulse generators in gene transfer and drug delivery, (2) development of electric pulse generators for utilizing them in gene transfer and drug delivery, (3) study of parameters of electric pulses used in gene transfer and drug delivery, (4) study of electrode configurations used in gene transfer and drug delivery.

Keywords: Electroporation, electric pulse generators, gene transfer, drug delivery, electrode configurations, Gene, Electic Pulse, Drug, Delivery, Electrode, Clinical Studies, DNA, liposomes, biological vectors

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Article Details

VOLUME: 14
ISSUE: 3
Year: 2013
Page: [319 - 323]
Pages: 5
DOI: 10.2174/1389200211314030007
Price: $65

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