Abstract
Field asymmetric waveform ion mobility spectrometry (FAIMS) is a gas-phase atmospheric pressure separation technique that exploits the difference in the mobility of an ion in alternating low and high electric fields applied between two closely spaced electrodes. FAIMS has the potential to simplify mass spectra by separating complex mixtures of ions, including isobaric ions, prior to mass spectral detection. It is a technique that is distinct from both chromatographic and mass-to-charge (m/z) separations. This mini-review discusses the principles of FAIMS separations and instrumentation and the application of FAIMS combined with mass spectrometry for the analysis of peptides and proteins.
Keywords: Gas phase separation, field asymmetric waveform ion mobility spectrometry, FAIMS, differential mobility spectrometry, mass spectrometry, peptide, protein, proteomics
Current Analytical Chemistry
Title:Field Asymmetric Waveform Ion Mobility Spectrometry Analysis of Proteins and Peptides: A Review
Volume: 9 Issue: 2
Author(s): Lauren J. Brown and Colin S. Creaser
Affiliation:
Keywords: Gas phase separation, field asymmetric waveform ion mobility spectrometry, FAIMS, differential mobility spectrometry, mass spectrometry, peptide, protein, proteomics
Abstract: Field asymmetric waveform ion mobility spectrometry (FAIMS) is a gas-phase atmospheric pressure separation technique that exploits the difference in the mobility of an ion in alternating low and high electric fields applied between two closely spaced electrodes. FAIMS has the potential to simplify mass spectra by separating complex mixtures of ions, including isobaric ions, prior to mass spectral detection. It is a technique that is distinct from both chromatographic and mass-to-charge (m/z) separations. This mini-review discusses the principles of FAIMS separations and instrumentation and the application of FAIMS combined with mass spectrometry for the analysis of peptides and proteins.
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Cite this article as:
J. Brown Lauren and S. Creaser Colin, Field Asymmetric Waveform Ion Mobility Spectrometry Analysis of Proteins and Peptides: A Review, Current Analytical Chemistry 2013; 9 (2) . https://dx.doi.org/10.2174/1573411011309020005
DOI https://dx.doi.org/10.2174/1573411011309020005 |
Print ISSN 1573-4110 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6727 |
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