Abstract
Raman spectroscopy is a promising technique for the identification and analysis of molecules in a sample without any labeling or modification. Since Raman scattering spectra provide information about intracellular molecular distributions, metabolism and chemical reactions, Raman microscopy has been widely utilized for bio-imaging and biofunctional analysis. By using metallic nanostructures, Raman scattering from molecules at the vicinity of a metal surface is significantly enhanced, which is called surface-enhanced Raman scattering (SERS). Due to localized field enhancement, the highly sensitive detection of molecules can be achieved and many attempts to apply it for biological and biomedical research have been made. In this article, we review the applications of metallic nanoparticles as SERS agents for molecular analysis and imaging of biological cells and tissues.
Keywords: Surface enhanced raman scattering, metallic nanoparticles, raman microscopy, biomolecular imaging, plasmonics, biophysics and biomedical science
Current Pharmaceutical Biotechnology
Title:Metallic Nanoparticles as SERS Agents for Biomolecular Imaging
Volume: 14 Issue: 2
Author(s): Jun Ando and Katsumasa Fujita
Affiliation:
Keywords: Surface enhanced raman scattering, metallic nanoparticles, raman microscopy, biomolecular imaging, plasmonics, biophysics and biomedical science
Abstract: Raman spectroscopy is a promising technique for the identification and analysis of molecules in a sample without any labeling or modification. Since Raman scattering spectra provide information about intracellular molecular distributions, metabolism and chemical reactions, Raman microscopy has been widely utilized for bio-imaging and biofunctional analysis. By using metallic nanostructures, Raman scattering from molecules at the vicinity of a metal surface is significantly enhanced, which is called surface-enhanced Raman scattering (SERS). Due to localized field enhancement, the highly sensitive detection of molecules can be achieved and many attempts to apply it for biological and biomedical research have been made. In this article, we review the applications of metallic nanoparticles as SERS agents for molecular analysis and imaging of biological cells and tissues.
Export Options
About this article
Cite this article as:
Ando Jun and Fujita Katsumasa, Metallic Nanoparticles as SERS Agents for Biomolecular Imaging, Current Pharmaceutical Biotechnology 2013; 14 (2) . https://dx.doi.org/10.2174/1389201011314020003
DOI https://dx.doi.org/10.2174/1389201011314020003 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Notch Signaling: A Potential Therapeutic Target in Prostate Cancer
Current Cancer Drug Targets Multiple Targeting by the Antitumor Drug Tamoxifen: A Structure-Activity Study
Current Medicinal Chemistry - Anti-Cancer Agents Nanocarriers for Respiratory Diseases Treatment: Recent Advances and Current Challenges
Current Topics in Medicinal Chemistry The Relationship Between Cleft Lip, Maxillary Hypoplasia, Hypoxia and Phenytoin
Current Pharmaceutical Design Targeted Inhibition of AKT in Pancreatic Cancer
Current Cancer Therapy Reviews Monoclonal Antibody Therapies Targeting Pancreatic Ductal Adenocarcinoma
Current Drug Discovery Technologies The Role of Mass Spectrometry in the “Omics” Era
Current Organic Chemistry Asymmetric Dimethylarginine: Clinical Significance and Novel Therapeutic Approaches
Current Medicinal Chemistry DNA Repair in Premature Aging Disorders and Neurodegeneration
Current Aging Science Functional Evaluation of Neural Stem Cell Differentiation by Single Cell Calcium Imaging
Current Stem Cell Research & Therapy New Approaches to Target Cancer Stem Cells: Current Scenario
Mini-Reviews in Medicinal Chemistry Manganese Superoxide Dismutase (Sod2) and Redox-Control of Signaling Events That Drive Metastasis
Anti-Cancer Agents in Medicinal Chemistry Managing Skin Malignancies- How Family Doctors, Plastic Surgeons, and Dermatologists Can Help
Current Cancer Therapy Reviews Crosstalk between IGF-1R and other Tumor Promoting Pathways
Current Pharmaceutical Design Impact of High Protein Intake on Viral Load and Hematological Parameters in HIV-infected Patients
Current HIV Research HER2 in the Era of Molecular Medicine: A Review
Current Cancer Therapy Reviews The Endothelin Axis: A Novel Target for Pharmacotherapy of Female Malignancies
Current Vascular Pharmacology microRNAs, Gap Junctional Intercellular Communication and Mesenchymal Stem Cells in Breast Cancer Metastasis
Current Cancer Therapy Reviews Cancer Chemoprevention Drug Targets
Current Drug Targets Vaccine Ingredients: Components that Influence Vaccine Efficacy
Mini-Reviews in Medicinal Chemistry