“Niu-Chang-Chih” (Antrodia cinnanomea) is a medicinal mushroom that has only been collected from the
aromatic tree, Cinnamomum kanehirai, which is native to Taiwan. A total of 105 Taiwan patent applications and patents
for “Niu-Chang-Chih” were collected and analyzed. Patent applications and granted patents claiming newly identified
functional components from “Niu-Chang-Chih,” biologically pure cultures of the mushroom strain, and cultivation of
“Niu-Chang-Chih” were examined. Several applications and patents claim identified active compounds from “Niu-Chang-
Chih,” which provide better patent protection. These newly identified functional compounds include cyclohexanones,
maleic and succinic acid derivatives, labdane diterpenoids, and benzenoids. Newly identified functional proteins include a
glutathione-dependent formaldehyde dehydrogenase (GFD), a glycoprotein named ACA1, and a laccase. Newly identified
functional polysaccharides include ACP1, ACP2, and ACP3. The number of patents for newly identified compounds and
their uses are expected to continue growing.
Keywords: Analysis, Antrodia cinnanomea, medicinal mushroom, Niu-Chang-Chi, patent, Taiwan, Mushroom strains, Maleic or Succinic Acid, Labdane diterpenoid, Cyclohexenone, Portfolio.
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