Abstract
Extracts of Scutellaria species have been used in Eastern traditional medicine as well in the Americas for the treatment of several human ailments, including cancer. Crude extracts or flavonoids derived from Scutellaria have been scientifically studied for potential anti-cancer activity using in vitro as well as animal models of various cancers, including breast cancer, prostate cancer, ovarian cancer and malignant gliomas. Phase I clinical studies have also been conducted to study the toxicity/efficacy of Scutellaria extract in patients with metastatic breast cancer. This article is a succinct review of pertinent research articles on the anti-tumor efficacy and associated molecular mechanisms of Scutellaria extracts, particularly those containing the flavonoid wogonin. The potential significance of Scutellaria flavonoids as an adjuvant therapy for malignant tumors is discussed.
Keywords: Scutellaria, flavonoid, wogonin, cancer, GSK-3, NF-κB, p38 MAPK.
Current Cancer Therapy Reviews
Title:Anti-cancer Scopes and Associated Mechanisms of Scutellaria Extract and Flavonoid Wogonin
Volume: 9 Issue: 1
Author(s): Paras S. Patel, Nirmal Joshee, Agnes M. Rimando and Prahlad Parajuli
Affiliation:
Keywords: Scutellaria, flavonoid, wogonin, cancer, GSK-3, NF-κB, p38 MAPK.
Abstract: Extracts of Scutellaria species have been used in Eastern traditional medicine as well in the Americas for the treatment of several human ailments, including cancer. Crude extracts or flavonoids derived from Scutellaria have been scientifically studied for potential anti-cancer activity using in vitro as well as animal models of various cancers, including breast cancer, prostate cancer, ovarian cancer and malignant gliomas. Phase I clinical studies have also been conducted to study the toxicity/efficacy of Scutellaria extract in patients with metastatic breast cancer. This article is a succinct review of pertinent research articles on the anti-tumor efficacy and associated molecular mechanisms of Scutellaria extracts, particularly those containing the flavonoid wogonin. The potential significance of Scutellaria flavonoids as an adjuvant therapy for malignant tumors is discussed.
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Patel S. Paras, Joshee Nirmal, Rimando M. Agnes and Parajuli Prahlad, Anti-cancer Scopes and Associated Mechanisms of Scutellaria Extract and Flavonoid Wogonin, Current Cancer Therapy Reviews 2013; 9 (1) . https://dx.doi.org/10.2174/1573394711309010004
DOI https://dx.doi.org/10.2174/1573394711309010004 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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