Title:Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay
VOLUME: 13 ISSUE: 3
Author(s):Dejan Godevac, Vele Tesevic, Vlatka Vajs, Slobodan Milosavljevic and Miroslava Stankovic
Affiliation:Institute of Chemistry, Technology and Metallurgy, Njegoseva 12, University of Belgrade, Serbia.
Keywords:Antioxidants, CBMN assay, Heterocyclic compounds, Human lymphocytes DNA
Abstract:This article summarizes the results of using cytokinesis-block micronucleus (CBMN) assay to evaluate the
antioxidant potential of heterocyclic compounds. Most studies were carried out with naturally occurring heterocyclic
compounds such as plant polyphenols: flavonoids, xanthones, coumarins, and ellagitannins, or plant derived products
(juices, extracts, supplements) rich in bioactive heterocyclic compounds. There are also some studies dealing with
synthetic heterocyclic antioxidants. CBMN assay is an in vitro study that has been used to evaluate antioxidant and
protective effects of heterocyclic compounds on induced chromosome aberration in human lymphocytes.
