Experimental and Theoretical Advances in Functional Understanding of Flavonoids as Anti-Tumor Agents

Author(s): Bandarugattu V. Babu, Naveen K. Konduru, Waro Nakanishi, Satoko Hayashi, Naseem Ahmed, Petar M. Mitrasinovic

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 13 , Issue 2 , 2013

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The potential of flavonoids to act as anti-tumor agents has been recognized but not fully understood because flavonoids are acting at several stages in cancer progression with distinct structure-function relationships. A whole family of structurally different flavonoids is herein described by reviewing some critical aspects of their pro-oxidant behavior in vitro/vivo and in cell systems by which they may work as antioxidants. Different classes of flavonoids (chalcones, flavones, isoflavones, flavanols, flavanones and anthocyanins) are synthetically mimicked using natural product structure-antioxidant activity relationships that are relevant for their enhanced function against cancer as well as severe inflammation conditions under which an increased oxidative stress is often implicated. In the context of the common mechanisms of flavonoid action, clinical data on benefits of flavonoids in fighting against cancer are discussed. A structural basis needed to improve antioxidant activity of these agents is elaborated in more detail.

Keywords: Action, Anthocyanin, Anti-cancer agent, Antioxidant, Anti-tumor activity, Cell line, Chalcone, Clinical data, Cytotoxic activity, Flavone, Flavonoid, Flavanol, Flavanone, Flavopiridol, Function, Isoflavone, Mechanism, Quercetin, SAR, Structure

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Article Details

Year: 2013
Published on: 15 January, 2013
Page: [307 - 332]
Pages: 26
DOI: 10.2174/1871520611313020017
Price: $65

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