Heterocyclic Chalcone Analogues as Potential Anticancer Agents

Author(s): Vikas Sharma, Vipin Kumar, Pradeep Kumar

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 13 , Issue 3 , 2013

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Chalcones, aromatic ketones and enones acting as the precursor for flavonoids such as Quercetin, are known for their anticancer effects. Although, parent chalcones consist of two aromatic rings joined by a three-carbon α,β-unsaturated carbonyl system, various synthetic compounds possessing heterocyclic rings like pyrazole, indole etc. are well known and proved to be effective anticancer agents. In addition to their use as anticancer agents in cancer cell lines, heterocyclic analogues are reported to be effective even against resistant cell lines. In this connection, we hereby highlight the potential of various heterocyclic chalcone analogues as anticancer agents with a brief summary about therapeutic potential of chalcones, mechanism of anticancer action of various chalcone analogues, and current and future prospects related to the chalcones-derived anticancer research. Furthermore, some key points regarding chalcone analogues have been reviewed by analyzing their medicinal properties.

Keywords: Anticancer agents, Chalcone analogues, Heterocyclic chalcone analogues, indolyl chalcones, synthesized novel chalcone linked imidazolones, pyridyl chalcones, coumarin chalcone, ferrocene, glioblastoma, pyrazolic chalcones.

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Article Details

Year: 2013
Published on: 14 January, 2013
Page: [422 - 432]
Pages: 11
DOI: 10.2174/1871520611313030006
Price: $65

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