Title:Heterocyclic Chalcone Analogues as Potential Anticancer Agents
VOLUME: 13 ISSUE: 3
Author(s):Vikas Sharma, Vipin Kumar and Pradeep Kumar
Affiliation:Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, India.
Keywords:Anticancer agents, Chalcone analogues, Heterocyclic chalcone analogues, indolyl chalcones, synthesized novel
chalcone linked imidazolones, pyridyl chalcones, coumarin chalcone, ferrocene, glioblastoma, pyrazolic chalcones.
Abstract:Chalcones, aromatic ketones and enones acting as the precursor for flavonoids such as Quercetin, are known for their
anticancer effects. Although, parent chalcones consist of two aromatic rings joined by a three-carbon α,β-unsaturated carbonyl system,
various synthetic compounds possessing heterocyclic rings like pyrazole, indole etc. are well known and proved to be effective anticancer
agents. In addition to their use as anticancer agents in cancer cell lines, heterocyclic analogues are reported to be effective even against
resistant cell lines. In this connection, we hereby highlight the potential of various heterocyclic chalcone analogues as anticancer agents
with a brief summary about therapeutic potential of chalcones, mechanism of anticancer action of various chalcone analogues, and
current and future prospects related to the chalcones-derived anticancer research. Furthermore, some key points regarding chalcone
analogues have been reviewed by analyzing their medicinal properties.
