Advances in Organic Synthesis

Volume: 5

Indexed in: Scopus, EBSCO, Ulrich's Periodicals Directory

Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. It presents comprehensive articles written by eminent authorities ...
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An Update on Trifluoromethylation of Carbonyl Compounds

Pp. 279-308 (30)

Nubia Boechat and Monica Macedo Bastos


This chapter reviews the recent findings on the synthetic methods developed for the direct introduction of a trifluoromethyl group in carbonyl compounds. It was organized by type of reagent highly considering the description of the trifluoromethylating agents, their activation mode, their asymmetric approaches, as well as applications in organic synthesis.


DAST, fluorine chemistry, trifluoromethyl halides, sulfur tetrafluoride, deoxo-fluor, bromine trifluoride, organoboron reagent, diethyl trifluoromethylphosphonate, trifluoromethyl bromide, fluoroform, hemiaminals of fluoral, sodium trifluoroacetate, sodium trifluoromethylacetophenone-N, Ndimethyltrimethylsilylamine adduct.


Fundação Oswaldo Cruz, Farmanguinhos, Rua Sizenando Nabuco, 100 CEP 21041-250 Manguinhos - Rio de Janeiro, RJ, Brazil